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23 reported that some caffeine metabolites were significantly increased in the urine of smokers compared with that of non-tobacco consumers

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Green Tobacco Sickness (GTS), an acute form of nicotine toxicity that results from absorption of nicotine through the skin ails workers engaged in tobacco cultivation

The data showed that IQOS crossed the developmental toxicity threshold at five times higher concentration than CS, unlike e-cigarettes that did not cross the threshold at maximum tested concentrations 32